Dimethyl Sulfoxide (DMSO) 100ml

DMSO - Dimethyl sulfoxide (99,9%) (CH₃)₂SO

Pharmaceutical Grade

Size: 100ml

It is an organosulfur compound with the formula (CH₃)₂SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. DMSO has the unusual property that many individuals perceive a garlic-like taste in the mouth after DMSO makes contact with their skin.

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 How to use

• Wash body parts before use, as DMSO has transdermal qualities and can pass through the skin and into the tissue below and the bloodstream.
• Always use chemically-free soap to wash the area of application.
• Always test on skin before use.
• Mix 60% DMSO with 40% Distilled water for topical use.
• Use only a few drops with water if digested.
• Always study the specific protocol, to learn how many drops to use in a certain amount of liquid.
• Can be mixed with Chlorine dioxide.

How DMSO works

DMSO is absorbed rapidly through the skin.

DMSO has transdermal properties, which means it passes through the skin, into the tissues below, and into the bloodstream. This is why the skin must be cleaned of any chemicals that must not reach the bloodstream during application.

Benefits of DMSO

DMSO shows approximately 40 pharmacologic properties that may be advantageous in the prevention, symptomatic relief, or pathology reversal of the human organic disease.

Following are sixteen of its major therapeutic properties:

1. It blocks pain by interrupting conduction in the small c-fibers, the nonmyelinated nerve fibers.
2. It is anti-inflammatory.
3. It is bacteriostatic, fungistatic, and virostatic.
4. It transports numerous pharmaceuticals across membranes.
5. It reduces the incidence of platelet thrombi in blood vessels.
6. It has a specific effect on cardiac contractility by inhibiting calcium to reduce the workload of the heart.
7. It acts as a tranquilizer even when simply rubbed into the skin.
8. It enhances antifungal and antibacterial agents when combined with them.
9. It is a vasodilator, probably related to histamine release in the cells and prostaglandin inhibition.
10. It inhibits the release of cholinesterase.
11. It tends to soften collagen by its peculiar cross-linking effect.
12. It scavenges the hydroxyl free radical.
13. It stimulates various types of immunity.
14. It is a potent diuretic, especially when administered intravenously.
15. It brings about interferon formation in the organism.
16. It stimulates the healing of wounds.

(Courtesy of DMSO Nature’s Healer by Dr. Morton Walker)

 Uses for DMSO

Muscle relaxant | Removal of toxins | Heavy metal detoxifier | Pain killer | Reduces inflammation & swelling | Protects against radiation | Promotes DNA repair | Restrains bacterial growth | Increases vasodilation | Repairs wounds & Ulcers | Works as an anti-inflammatory agent |Anti-microbial properties | Increases delivery of oxygen to the cells | Has a calming effect on the central nervous system.

Precautions if DMSO is taken orally

• Consult medical advice before drinking DMSO.
• Consult medical advice when using medication.
• Do not use when pregnant or breastfeeding.
• Causes a garlic-like taste and breath and body odor.
• Always dilute with water if taken orally.
• Poisonous if taken at full strength.

Topical use

• Test before applying on the affected area for allergic reaction or causing redness of the skin.
• Recommended mixing starting procedure is 40% DMSO with 60% distilled water.
• 100% application can be used but will cause itching of the application area.
• If using bare hands to apply DMSO, do not wear nail polish. It will dissolve the polish and will carry its toxic ingredients through the skin and into the body.
• After application, simply rinse hands with clean water.

Warning

• Do NOT take DMSO and Calcium hypochlorite (MMS2)together!
• Wear personal protective equipment when handling DMSO.
• Ensure adequate ventilation.
• Keep away from children.
• Keep away from open flames, hot surfaces, and sources of ignition.
• Avoid inhalation of fumes.
• Keep the bottle tightly closed and store it in a dry & cool place and work with it in a well-ventilated area.
• Will crystallize in cold temperature conditions.
• At full strength, avoid contact with skin, eyes, or clothing.

Biological actions of DMSO and their clinical significance

1984 - Clinical Considerations of Dimethyl Sulfoxide - (Linda K. Wong - Iowa State University, Eric L. Reinertson - Iowa State University)

Dimethyl sulfoxide has a multitude of biological actions which have been demonstrated in the laboratory and also in clinical situations. Many of the pharmacolog~calproperties of DMSO are still under laboratory investigation and have not yet been extended to use in the field of veterinary medicine. However, with additional research into the potential uses of DMSO, it may prove to have an amazing diversity of applications in the medical field.

Membrane Penetration

DMSO readily crosses most tissues of animals and man with the exception of tooth enamel and keratinized structures. The exact mechanism involved in the membrane-penetrant action of DMSO has yet to be elucidated. It has been hypothesized that DMSO substitutes for water in the skin causing a reversible configurational change of the skin protein, thus accounting for the rapid passage of DMSO through the skin.  The ability to penetrate body membranes and to become widely distributed throughout the body is advantageous, especially the ability of DMSO to transport other pharmacological agents through the skin and other biological membranes.

Membrane Transport

DMSO can serve as a vehicle for topical drugs and facilitate their transport through the skin. DMSO carries substances rapidly and deeply into the horny layer of the skin. non-ionized molecules of low molecular weight are transported through the skin with DMSO, but substances of high molecular weight do not pass through the skin with DMSO to any significant extent. This ability to enhance percutaneous penetration of topical medications lends itself well to use in limitation to topical therapy is the skin's protective characteristics. DMSO has been found to enhance the penetration of the following therapeutic agents: Antibacterials, antivirals, estrogens, corticosteroids, anti-parasitics, and local anesthetics. In one human case, DMSO was used to maintain nourishment by percutaneous absorption of nutrients dissolved in DMSO.  Most evidence indicates that DMSO itself, does not have healing properties in the majority of dermatological disorders, but its ability to serve as a vehicle for the transfer of drugs through the intact skin and for deposition of these drugs into the skin is its beneficial effect.

Anti-Inflammation

DMSO has significant anti-inflammatory properties. Researchers indicate that the anti-inflammatory effect of DMSO may be due to its ability to scavenge inflammation-triggering free radicals and/or its ability to inhibit the influx of polymorphonuclear cells and monocytes into the sites of inflammation. One of the most popular uses of DMSO is for the treatment of acute
swelling associated with traumatic injuries.

Another use of DMSO which utilizes its anti-inflammatory properties is in the treatment of toxic snake bites. It is thought that the use of DMSO decreases the swelling resulting from the snake bite, and it also potentiates the action of the administered corticosteroids. DMSO also decreases the inflammation associated with perivascular injections of thiacetarsamide sodium. DMSO decreases the swelling and dissipates this irritating anti-parasitic, and thus prevents sloughing of surrounding tissues. DMSO is also used in the treatment regime for otitis externa to reduce irritation. Treatment of ulcers and wounds is also augmented by DMSO therapy, in part due to its anti-inflammatory properties. The topical application of DMSO to canine mammary glands reduces swelling and engorgement. DMSO has also been used to relieve post-operative pain and swelling following joint and tendon repair procedures. 

Analgesia

DMSO alone has analgesic properties, and when used in conjunction with topical anesthetics appears to potentiate their effects. DMSO reversibly decreases the conduction velocity of nerves and produces analgesia by acting on both the peripheral nervous system and the central nervous system. Subcutaneous injection of 10% DMSO can result in a total loss of central recognition of pain. 
DMSO produces an analgesic effect comparable to morphine, but it is long-lasting and is not reversible by the administration of naloxone. Since it is not reversed by naloxone, this indicates that opiate receptors are not involved in DMSO-induced analgesia. DMSO can also induce total anesthesia of an animal when injected into the cerebral spinal fluid without apparent adverse reactions. However, the clinical application of this method of anesthesia is impractical.

Effects on Connective Tissue

DMSO decreases the concentration of collagen and its metabolites and also reduces the pathogenic deposition of collagen in response to injury. Experimentally, DMSO injected intraperitoneally will decrease the incidence of intestinal adhesions. This inlay proves useful for post-operative treatment of gastrointestinal surgery. Studies involving the use of DMSO for the treatment of collagen-related arthritis resulted in conflicting results and require further studies to determine the efficacy of DMSO in treating this disorder.

Effect on Bacteria, Fungi, and Viruses

DMSO exhibits a remarkable inhibitory effect on a wide range of bacteria, fungi, and both RNA and DNA viruses. The bacteriostatic effect of DMSO may occur due to a loss of RNA conformational structure required for protein synthesis. Pre-treatment with DMSO restored and increased the sensitivity of antibiotic-resistant strains of bacteria and increased the sensitivity of bacteria in general to antibiotic treatment. This characteristic of DMSO may prove to be valuable.

Diuresis

DMSO is an effective diuretic due to an increase in the urinary excretion of sodium and potassium. This diuretic effect may prove valuable in treating cases of central nervous system trauma because the diuretic effect of DMSO is effective in decreasing intracranial pressure.  In man, intravenous DMSO is more effective than mannitol, urea, cortisone, or barbiturates for reducing intracranial pressure associated with severe head injuries. 

Vasodilation

DMSO has potent histamine-releasing properties which result in significant vasodilation.  This vasodilatory effect may be useful in decreasing edema, improving circulation in localized areas, and increasing the absorption of other drugs. DMSO vasodilation increases the cortical and spinal blood flow, thus reducing the edema resulting from acute cranial and spinal cord trauma. Experimentally, DMSO has been used to treat intestinal, renal, and cerebral ischemia.

Action on Free-Radicals

DMSO can scavenge free radicals, especially hydroxyl radicals and hydrogen atoms.  The carcinogenic effect of many organic compounds is related to the formation of free-radical intermediates. It has been shown that DMSO causes significant inhibition of promoters of neoplasia, with a reduction of both tumor rate and yield. DMSO has also been shown to protect tissues and cells against radiation damage. This protective effect is due to the inhibition of hydroxyl radicals by DMSO. The scavenging of free radicals also aids in the reduction of pain induced by inflammation. DMSO has been shown to increase the effectiveness of griseofulvin and potentiate the action of digitoxin. This is clinically important when using DMSO concomitantly with other therapeutic agents.